Morphological studies on middle ear barotrauma in guinea pigs.

Effect of trans-retinoic acid in the inhibition of cholesteatoma in guinea pigs.

UNLABELLED Middle ear cholesteatoma affected more than 5 million people until the 80;s. Many animal models were used, unsuccessfully, to study an alternative therapy to cholesteatoma. AIM observe the effect of the trans-retinoic acid in the inhibition of middle ear cholesteatomas induced by propylene glycol. STUDY DESIGN Clinical and Experimental. METHODS 25 guinea pigs were submitted to ...

Protective effect of neurotrophic agent T-817MA against inner ear barotrauma in the guinea pig.

T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}azetidin-3-ol maleate), a neurotrophic compound newly synthesized for the treatment of Alzheimer's disease, has been found to reduce oxidative stress and exert neuroprotective effects. By assessing the auditory functioning and observing the cochlear sensory epithelia, we investigated whether T-817MA protects the cochlea from inner ear barotra...

Studies on the rapid production of Foot and Mouth disease hypenmmune antisera in guinea pigs

Protective effect of melatonin on experimental otitis media with effusion in guinea pigs.

The aims of this study were: (a) to assess whether the increased oxidative stress in otitis media with effusion (OME) induced in guinea pigs by histamine injection into the middle ear cavity is reflected by lipid peroxidation in erythrocytes, plasma, and middle ear effusion fluid; (b) to survey the alterations of oxidant and antioxidant enzyme activities in experimental OME; and (c) to determin...

Changes in the Middle Ear Mucosa of Guinea Pigs After the Insertion of Preserved Teeth: A Pathologic Study

OBJECTIVE: In this study, we analyzed the pathologic changes in the middle ear mucosa after the insertion of preserved allograft teeth in guinea pigs by examining serial sections under the light microscope. MATERIALS AND METHODS: Sixteen pigmented guinea pigs were included in this 2-stage study. In the first stage, 2 guinea pigs were killed, and a preservation technique that included autoclave ...